Order Sedative and Hypnotic Drugs Discussion

Order Sedative and Hypnotic Drugs Discussion
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Order Sedative and Hypnotic Drugs Discussion
Order Sedative and Hypnotic Drugs Discussion
Directions for questions 1−6
Match each sedative-hypnotic drug w ith the appropriate description (each lettered option can be selected once, m ore than once,
or not at all).
A. Alprazolam
B. Buspirone
C. Clonazepam
D. Flum azenil
E. Flunitrazepam
F. Lorazepam
G. Midazolam
H. Phenobarbital
I. Thiopental
J. Zolpidem
Di culty level: Easy
1. A partial agonist at serotonin (5-hydroxytryptam ine, 5-HT)
5-HT1A receptors
Di culty level: Easy
2. A com petitive antagonist at benzodiazepine receptors
Di culty level: Easy
3. A hypnotic drug w ith negligible e ects on sleep architecture
and stages
Di culty level: Easy
4. The barbiturate m ost frequently used to induce general
Di culty level: Easy
5. A benzodiazepine w ith a very short half-life (about 2 hours)
Di culty level: Easy
6. An anxiolytic drug w ith negligible abuse liability
Di culty level: Medium
7. A 42-year-old m an recently diagnosed w ith generalized anxiety disorder had started a treatm ent w ith sertraline, but the
Order Sedative and Hypnotic Drugs Discussion
drug caused som e sexual dysfunction, and the psychiatrist decided to sw itch to a short course of alprazolam . Which of the
follow ing m olecular actions on neuronal m em branes m ost
likely m ediated the therapeutic e ect of alprazolam in the
patient’s disorder?
A. Decreased outward Na current
B. Increased inward Cl− current
C. Decreased outward K current
D. Increased inward Ca2 current
E. Increased inward H current
Di culty level: Medium
8. A 63-year-old wom an was referred to a psychiatrist because
of easy fatigue, worry, irritability, and di cult y concentrating. These sym ptom s had been present alm ost continuously
during the daytim e since she retired from her job as a schoolteacher 1 m onth ago. She told the doctor that those sym ptom s
were unbearable and that she wanted to die. A prelim inary
diagnosis of severe generalized anxiet y disorder was m ade,
and a treatm ent w ith sertraline and diazepam was prescribed.
Which of the follow ing adverse e ects were m ost likely to
occur during the rst days of therapy?
A. Excitem ent and irritability
B. Mental confusion and anterograde am nesia
C. Excessive sedation and drowsiness
D. Respiratory depression and apnea
E. Disturbing dream s and early awakening
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