Introduction to Pharmacology Paper

Introduction to Pharmacology Paper
1. An example of a drug’s mechanism of action would be:
a. blockade of serotonin receptors
b. inhibition of muramic acid crosslinking in a bacterial cell wall
c. decreased infl ammation
d. a and b only
2. An adverse effect is:
a. an unwanted effect
b. a potentially toxic effect
c. an effect that only occurs at high doses
d. a and b
3. An example of a drug-induced toxic effect would be:
a. hearing loss produced by gentamicin
b. nephrotoxicity produced by cisplatin
c. congestive heart failure produced by doxorubicin (Adriamycin)
d. all of the above
4. The monoamine oxidase inhibitor tranylcypromine inhibits the metabolism of norepinephrine. It
may produce a hypertensive crisis if certain foods are eaten during therapy. Phenelzine, another
monoamine oxidase inhibitor, would most likely:
a. have similar effects
b. have the same mechanism of action as tranylcypromine, but not have food interactions
c. have a different adverse effect profi le
d. act completely differently
5. Tetracyclines are drugs of choice for rickettsial infections, such as Rocky Mountain Spotted Fever.
This means that they:
a. are the only drugs effective against the condition
b. are the most effective drugs for the condition
c. are the fi rst drugs to be prescribed
d. are the only drugs prescribed
6. Which of the following drugs would require a dosage adjustment in a 70-year-old patient?
a. Cefaclor (eliminated in the urine)
b. Oxazepam (eliminated through the bile)
c. both a and b
d. neither drug would require dosage adjustment
7. A patient is taking phenelzine. With each dose of drug:
a. plasma levels of drug rise
b. plasma levels of drug remain the same, as the drug is stored
c. plasma levels of drug rise and then fall as the drug is distributed
d. more and more drug binds to proteins in the liver
8. A patient with cirrhosis of the liver is prescribed a fat-soluble drug (e.g., Valium). Which of the
following could occur?
a. plasma levels will reach toxic levels, as the drug cannot be cleared properly
b. renal failure will occur
c. a loss of activity may occur, as the drug could not be transformed into its active form
d. either a or c could occur
9. Which of the following is not absorbed?
a. a 40 mg Lasix tablet
b. Nicotine from a transdermal patch
c. Compazine from a rectal suppository
d. 100,000 units penicillin G potassium in an intravenous drip

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